"Hillary is going to run," said Buffett, the chairman and chief executive of conglomerate Berkshire Hathaway Inc, speaking at Fortune's Most Powerful Women Summit in Laguna Niguel, California.
"Hillary's going to win," said Buffett, saying he'd be willing to "bet money on it."
Buffett is ranked by Forbes as the third-richest person in the world.
Speculation has swirled whether former secretary of state Clinton will throw her hat into the ring for the next election. While she is considered a potential contender for the job, she herself has yet to announce her decision on running.
"She's going to announce it as late as possible," Buffett said.
Buffett also added that he expected a pick-up in US homebuilding as young people marry and create households of their own.
"We will have a catch up period," he said. "It (homebuilding) will improve."
The S&P homebuilding index is down about 5 percent in 2014 but has risen about 157 percent since 2008 and the financial crisis.
Buffett — whose Berkshire Hathaway owns dozens of businesses ranging from ice cream to insurance — also said that banks are not as profitable as they were previously.
"What was a very profitable business has been turned into a good business if executed well," Buffett said of the largest US banks. Among Berkshire Hathaway's stock portfolio is a significant stake in Wells Fargo.
A decade ago or more, Buffett said, the best banks were "ungodly profitable."
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