The 'Everybody's Somebody's Fool' star's wife, Jeanie Scott, said he died of cardiac arrest at their Las Vegas home, reported The Guardian.
He had battled health problems stemming from a genetic hormone deficiency and had been under the care of a home nurse.
"He was an Earth angel. He was different from any person I ever met. He was kind, humble. Everyone he met he made them feel special. He had a hard life, but he didn't hold any resentment," Jeannie Scott said.
She said her husband stopped touring two years ago but continued recording. He is expected to be buried in Cleveland.
The vocalist, whose first major hit was 'Everybody's Somebody's Fool' in 1949, alongside the Lionel Hampton Band, gathered new generations of fans during the 1960s and in the 1990s when he toured with Lou Reed and sang on the track, 'Sycamore Trees' for the series finale of 'Twin Peaks'.
Born into a family of 10 in Cleveland, Ohio, on July 17 1925, Scott sang in a church choir as a child. His signature high voice came from Kallmann's syndrome, which kept him from experiencing puberty and stunted his growth.
He stood just under five feet as an adult and his voice did not change.
Although that trait ultimately helped Scott stand out as a singer, he also suffered from congestive heart failure and had a lifestyle that included heavy drinking and smoking.
Despite his youthful sound, Scott brought heavy emotion to his delivery, often dramatically drawing out lyrics and singing far behind the beat and won praise for this technique.
The album 'Falling in Love Is Wonderful' in 1960s, is widely considered to be his masterpiece, although he largely disappeared from view until his 1990s career revival.
Scott performed at Dwight Eisenhower's and Bill Clinton's presidential inaugurations and was inducted into the R&B Music Hall of Fame in 2013.
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