Seeking to build on an interim agreement reached late last year in Geneva, Iran and the major powers aim to hammer out a final settlement of the decade-old dispute over Tehran's atomic activities by late July.
The March 5-7 meeting at the United Nations complex in Vienna, which ended around mid-day on Friday, was to prepare for the next round of political negotiations on the issue later this month, also in the Austrian capital.
Both sides have made clear their political will to reach a long-term accord and have scheduled a series of meetings in the coming months. But they also acknowledge that there are still big differences over the future scope of Iran's nuclear programme and that success is far from guaranteed.
"The talks are very serious and substantive and useful," the head of the Iranian delegation at the expert-level talks, senior foreign ministry official Hamid Baidinejad, told Iran's Fars news agency ahead of Friday's session.
There was no immediate comment from either side after the meeting ended.
Officials said experts from Russia were taking part in this week's meeting in Vienna, suggesting there was no immediate impact on the nuclear negotiations from the crisis in Ukraine.
A senior diplomat from one of the big powers said this week there had been "no suggestion by anyone" that the crisis would impede discussions on Iran or other issues such as Syria where the United States and Europe are trying to cooperate with Russia.
Western officials want Iran to significantly scale back its uranium enrichment activities to ensure that it would be unable to build an atomic bomb quickly if it ever decided to do so.
Iran denies allegations that it is seeking the technical know-how and means to assemble nuclear weapons and says it will not shut any of its nuclear sites, which include the uranium enrichment plants at Natanz and Fordow and a planned heavy water reactor at Arak.
An official of Iran's atomic energy organisation earlier this week said the negotiations would be "time consuming."
"We want to continue our activities. Some on the other side have imaginary concerns about us veering from non-peaceful use (of nuclear energy). We are studying ways to remove that," Behrooz Kamalvandi told Iran's IRNA news agency on Wednesday.
Iran wants Western and UN sanctions that are severely hurting its oil-dependent economy lifted, having won limited relief in exchange for curbing its most sensitive nuclear work under the six-month Geneva deal, which took effect on Jan. 20.
Uranium can be used to fuel a planned network of nuclear power plants, which is Iran's stated goal, but also provide fuel for bombs if processed to a high fissile concentration, which the West fears may be Iran's ultimate aim.
Chief negotiators from Iran and the powers — the United States, France, Russia, Britain, Germany and China — are to begin their next round of negotiations on March 18 in Vienna. The meeting is expected to last two to three days.